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HNU, ISMS, CCDC and Sun Yat-sen University Develop One-stop Platform for Early Warnings of Influenza A Virus

HNU, working together with the Suzhou Institute of Systems Medicine (ISMS) of the Chinese Academy of Medical Sciences, the Chinese Center for Disease Control and Prevention (CCDC), and Sun Yat-sen University, developed a one-stop platform for early warnings of the influenza A virus – FluPhenotype. A related paperFluPhenotype-a one-stop platform for early warnings of the influenza A viruswas published on international bioinformatics journalBioinformatics.

The major authors include: Lu Congyu, postgraduate student of HNU College of Biology; Cai Zena, doctoral candidate of HNU College of Biology; Peng Yousong, associate professor of HNU College of Biology; and, Jiang Taijiao, professor of ISMS.

The FluPhenotype is a one-stop platform to rapidly determine the phenotypes of the influenza A viruses. The input of FluPhenotype is the complete or partial genomic/protein sequences of the influenza A viruses. The output presents five types of information about the viruses: 1) sequence annotation including the gene and protein names as well as the open reading frames, 2) potential hosts and human-adaptation-associated amino acid markers, 3) antigenic and genetic relationships with the vaccine strains of different HA subtypes, 4) mammalian virulence-related amino acid markers, and 5) drug resistance-related amino acid markers. FluPhenotype will be a useful bioinformatic tool for surveillance and early warnings of the newly emerging influenza A viruses. (Source:https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btaa083/5734644?guestAccessKey=21482286-0b4f-4c8c-9727-9bf1a19ef4b4)

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