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HNU, ISMS, CCDC Reveal Difference between COVID-19 and SARS

HNU, working together with the Suzhou Institute of Systems Medicine (ISMS) of the Chinese Academy of Medical Sciences and the Chinese Center for Disease Control and Prevention (CCDC), published a paperGenome Composition and Divergence of the Novel Coronavirus(2019-nCoV) Originating in Chinaon international academic journalCell Host & Microbe.

The paper gives an in-depth annotation of the newly discovered coronavirus (COVID-19) genome and reveals difference between COVID-19 and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.

The main authors contributed equally are: Wu Aiping, researcher of ISMS; Peng Yousong, associate professor of HNU College of Biology; Huang Baoying, researchers of CCDC; and, Ding Xiao, associate researcher of ISMS.

Genome composition and phylogenetic tree for COVID-19

A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of COVID-19.

Amino Acid Substitutions of COVID-19 against SARS and SARS-like Viruses

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